Diagnosed 1/12 with lung cancer out of the blue. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. View the data on GreenMedInfos Hypothyroidism Research page. This is a horrible disease that ravages the body. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). Find how some diseases can be healed with alternative medicine, and share your experience with You are using an out of date browser. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? Increased sensitivity to cold. Thyroid dysfunction after immune checkpoint inhibitor treatment in a Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Patients with undertreated hypothyroidism at higher risk for longer Even in the mildest form, hypothyroidism affects the heart. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. [13] Hollowell JG, Staehling NW, Flanders WD, et al. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. PLoSone 2011, 11:e27547. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called 'active ingredient' T4 versus the natural variations in hormone concentrations found in the 'real thing,' which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. [14] In other words, you can normalize the main clinically measurable parameter associated with low thyroid function, i.e. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. I am just as much in the dark as some others on this site. International Journal of Human Nutrition and Functional Medicine, Black Seed May Treat Hypothyroidism (Hashimotos Disease), Clinical Trial Reveals, Wi-Fi Devices Increase Mercury Release From Dental Amalgams, Participating in Drum Circles Improves Health and Quality of Life in Parkinsons Patients (Study), Acupuncture Beats Injected Morphine for Pain: Groundbreaking Study, Mammography Is Harmful and Should Be Abandoned, Scientific Review Concludes, Killer Germs Obliterated by Medicinal Smoke Smudging, Study Reveals, Turmerics Smart Kill Properties Put Chemo & Radiation To Shame, Beet Juice Boosts Cognitive Function In One Dose, 13 Evidence-Based Medicinal Properties of Coconut Oil, Group Drumming Better Than Prozac, Study Suggests, 25 Cancer Stem-Cell Killing Foods That Are Smarter Than Chemo and Radiation, Ibuprofen Can Stop Your Heart 31% Increase in Cardiac Arrest Risk, Conscious Shopping Offering Conscious Products for Conscious People, Uncovering The Truths And Myths About 3 Superstar Herbs, Living Past 100: The Okinawan Diet and Blue Zone Centenarians, Repairs DNA and Rejuvenates Your Cells While You Relax, Why Daily Greens are the Real Fountain of Youth, T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. I wish I could say that my story was atypical. Why not simply call it selenium deficiency? This discussion has been closed to comments. Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. Assessment of oxidative stress and its balance has not been taken into consideration up to now as it should be.". [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)". UpToDate [4], DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. Hypothyroidism (underactive thyroid) - Diagnosis and treatment - Mayo Iodine - and the lack of it - is implicated in breast cancer, after all. Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. millions treated for hypothyroidism at risk for lung cancer Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. As I have lung cancer and just recently was diagnosed hypothyroidI am very interested as to what you have to say about this connection.your personal insight and any books, websites would be appreciated.you may email me if you prefer. El almacenamiento o acceso tcnico que se utiliza exclusivamente con fines estadsticos annimos. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. Thyroid dysfunction after immune checkpoint inhibitor treatment in a single-center Chinese cohort: a retrospective study Brit Med J 1978, 1:210212. Why not simply call it selenium deficiency? Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. In an attempt to show causation, the article notes "patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. The authors expanded on their findings further: "However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. [4], More recently DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. Angiology 2000, 51:S65S68. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. Baked or Fried avocado fries [Vegetarian]. A total of 425 inpatients with malignant tumors were treated with ICIs at PUMCH during the study period. If people do not wish to find out all they can about their disease that is fine too. Study: Millions Treated for - The Wellness Institute | Facebook An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Non-small cell lung cancer is the most common type of lung cancer, accounting for about 81% of all cases. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. My Endocrinologist was, and continues to be, open about the elevated risk for thyroid cancer due to the multiple. Reddit and its partners use cookies and similar technologies to provide you with a better experience. 2013 May ;98(5):1982-90. Non-ASPS articles which could be relevant. Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. PMID 11836274. A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' I can understand why tennis 123 wrote, "I have so much to say about this I could write a book". 16.6k members in the AlternativeHealth community. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Angiology 2000, 51:S65S68. I think there is always a lot of confusion with cause and cure. A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). arizona lockdown status today; tiktok unblocked from school; samantha and savannah concepcion Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. Tokushima J Exp Med 1991, 38:2535. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? [13] Hollowell JG, Staehling NW, Flanders WD. 2004 Jun;9(2):157-79. J Clin Endocrinol Metab. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. Overtreatment, of course, is the hallmark danger of overdiagnosis. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. Monaldi Arch Chest Dis 2003, 59:140145. But what can be done for patients who are at low Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. See more of Keri Topouzian, D.O. Just another excuse for keeping us on doses that are too low. It's possible, for instance, that the reason both sales of Synthroid and the incidence of lung cancer increased is due to an environmental condition that affected both the thyroid and the lungs. Merck Announces Phase 3 KEYNOTE-671 Trial Met Primary Endpoint of Event Millions of people who were not only wrongly diagnosed with cancers and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. For a better experience, please enable JavaScript in your browser before proceeding. However, they pointed out that the opposite was recently described, and that "hypothyroidism reduces theaggressiveness of some cancers because of the presence of thyroid hormone receptors oncancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness ofcancers."[1]. Savvy Senior: Could you have a thyroid problem and not even know it? The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. J Endocrinol Invest. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health.
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